Bystander effect radiation oncology

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August undefined, 2024

In clinical situations, surgical debulking of the primary tumour and possibly its draining lymph nodes is usually undertaken before any other intervention, whereas in fully immune-competent rodents, primary tumours are generally first subjected to irradiation.93 However, the magnitude of the antitumour immune … See more The tumour ecosystem in preclinical models differs from that in the clinical situation. In preclinical models, most tumours usually grow … See more Treatment planning includes the irradiation regimen itself as well as the treatment sequence with immunotherapy. In terms of ionising radiation, varying doses and fractionations in combination with immunotherapy are … See more WebSystemic mechanisms and effects of ionizing radiation: A new ⿿old⿿ paradigm of how the bystanders and distant can become the players Author links open overlay panel Zacharenia Nikitaki a 1 , Ifigeneia V. Mavragani a 1 , Danae A. Laskaratou a , Violeta Gika a , Vadim P. Moskvin b , Konstantinos Theofilatos c , Konstantinos Vougas d , Robert ...

Pharmaceutics Free Full-Text Advances in Targeted Therapy of …

WebApr 20, 2009 · Radiation-induced bystander responses have two main mechanisms of action, which mirror gene therapy bystander effects . For cells in direct contact, … WebOct 25, 2024 · Radiation-induced bystander effect (RIBE) is the ability of cells exposed to external effects to transmit the manifestation of the effect to cells not directly exposed to external effects; where RIBE mainly has … incoming template

Bystander Effect - an overview ScienceDirect Topics

WebFeb 3, 2024 · In radiation oncology, the modulation of the bystander effect is a target both for the de- struction of tumor cells and to protect healthy cells. With this objective, we determine whether the WebDec 20, 2024 · Radiation-induced bystander signals cause various side effects (i.e., RIBEs), which commonly appear as changes in the skin (such as itching, peeling, and blistering) and fatigue; other side effects, such as diarrhea, nausea, hair loss, and vomiting depend on the exposed area of the body. WebJan 1, 2015 · Radiation-induced bystander effects are defined as biological effects expressed after irradiation by cells whose nuclei have not been directly irradiated. These effects include DNA damage, chromosomal instability, mutation, and apoptosis. incoming telephone wiring diagram

Single-cell mechanistic studies of radiation-mediated bystander …

WebAug 28, 2014 · Radiation-induced bystander effects are defined as biological effects expressed after irradiation by cells whose nuclei have not been directly irradiated. … WebThe radiation-induced bystander effect ( bystander effect) is the phenomenon in which unirradiated cells exhibit irradiated effects as a result of signals received from nearby irradiated cells. In November 1992, Hatsumi Nagasawa and John B. Little first reported this radiobiological phenomenon. [1] incoming test gmpWeb2.2. LATTICE radiotherapy. Built upon the clinical experience of GRID SFRT, and inspired by the biological insights of bystander/abscopal effects, the technique of LATTICE … incoming thesaurus

"WebThe mechanism of bystander effect induced by different irradiation in human neuroblastoma cells. Author links open overlay panel Bo Chen a 1, Peng Zhang a 1, Feiyi Sun a, Bo Li a, Yu Chen a, Sizhu Pei a, Ziyin Zhang a, Robina Manzoor a, Yifan Deng a, Chunli Sun a, Li Sui b, Fuquan Kong b, Hong Ma a. Show more. " - Bystander effect radiation oncology

Bystander effect radiation oncology

Radiation-induced bystander signalling in cancer therapy

Webradiation therapy are probably killed by ionizing tracks directly interacting with the cell. However, in situations with low dose-rate radiation, e.g. radio-nuclide therapy, the bystander effect could have a different impact on the tumor cell survival and, in addition, killing of bystander cells might compensate for heterogeneous dose ... WebJan 1, 2015 · In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.

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WebThe long-range bystander effect is generated by cytokines, macromolecules, and exosomes liberated into the extracellular space ( 38, 40, 44) that, through the lymphatic or vascular systems, might … WebBackground: Knowledge of radiobiology is of paramount importance to be able to grasp and have an in-depth understanding of the consequences of ionizing radiation. One of the most important effects of this physical stressor's interaction to targeted and non-targeted cells, tissues and organs is on the late effects on the development of primary and secondary …

WebFeb 3, 2024 · In radiation oncology, the modulation of the bystander effect is a target both for the destruction of tumor cells and to protect healthy cells. With this objective, we determine whether the radioprotective capacity of rosmarinic acid (RA) can affect the intensity of these effects. WebJun 24, 2024 · The radiation-induced bystander effect (RIBE) was first reported as the phenomenon which involves the induction of sister chromatid exchanges (SCE) by extremely low doses of alpha particles in …

WebJan 9, 2015 · We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of large numbers of apoptotic B cells did not affect T cell functionality. In contrast, when PBMC were stored under unfavorable conditions, leading to damage and apoptosis in the T cells as … WebApr 6, 2024 · Cancer cells subjected to ionizing radiation may release signals which can influence nearby non-irradiated cells, termed bystander effects. The transmission of …

WebThe term bystander effect describes the ability of cells affected by irradiation to convey manifestations of damage to other cells not directly targeted for irradiation. An irradiated … incoming traffic does not stop signWebFeb 28, 2014 · The bystander effect has had a large impact on the field of radiation biology. The Web of Science tallies 7159 related records in their core collection. The experiments that we analyzed that are the focus of the two reports [ 1 , 2 ] published in Radiation Research , purport to extend the bystander effect to nuclear medicine, … incoming toscanaWebApr 5, 2024 · The laboratory measured the killing effect and the bystander effect manifested as micronucleus (MN) formation after irradiating primary human fibroblasts with charged … incoming texts still going to old phoneWebMar 1, 2012 · A great deal of evidence suggests that the application of ionizing radiation to a target volume that includes the tumor elicits effects that exceed radiation-induced cell death and also produces diffusible oxygen reactive species and secreted factors that have been identified as possible mediators in the indirect bystander effect [12], and it ... incoming thingsWebOct 4, 2002 · Studies in recent years have demonstrated that a radiobiologic phenomenon termed the “bystander effect” can be observed in mammalian cells grown in vitro. … incoming the movieWebIn radiation oncology, the modulation of the bystander effect is a target both for the destruction of tumor cells and to protect healthy cells. With this objective, we determine … incoming traffic 意味WebOct 25, 2024 · Radiation-induced bystander effect (RIBE) is the ability of cells exposed to external effects to transmit the manifestation of the effect to cells not directly exposed to … incoming threat assassin\u0027s creed origins